THE ROLE OF OXIDATIVE STRESS IN THE DEVELOPMENT AND PROGRESSION OF TYPE 2 DIABETES MELLITUS
Keywords:
type 2 diabetes mellitus, oxidative stress, insulin resistance, inflammation, metabolic dysfunctionAbstract
Oxidative stress is a key pathogenetic factor in the development and progression of type 2 diabetes mellitus. Excessive production of reactive oxygen species contributes to insulin resistance, pancreatic beta-cell dysfunction, endothelial injury, and chronic diabetic complications. The aim of this study was to analyze the role of oxidative stress in type 2 diabetes and evaluate its clinical significance. The findings indicate that oxidative imbalance interacts with inflammation, hyperglycemia, dyslipidemia, and mitochondrial dysfunction. Understanding these mechanisms may support preventive and therapeutic strategies aimed at reducing diabetic complications.
References
Kumar V., Abbas A. K., Aster J. C. Robbins and Cotran Pathologic Basis of Disease. 10th ed. Elsevier; 2021.
Harrison T. R. Harrison's Principles of Internal Medicine. 21st ed. McGraw-Hill; 2022.
Goldman L., Schafer A. I. Goldman-Cecil Medicine. 26th ed. Elsevier; 2020.
Fauci A. S., et al. Harrison's Manual of Medicine. McGraw-Hill; 2020.
Jameson J. L., et al. Endocrinology: Adult and Pediatric. Elsevier; 2016.
Loscalzo J. Harrison's Cardiovascular Medicine. McGraw-Hill; 2017.
Kuzieva, S. U., & Ishonkulova, D. U. (2018). VYDELENIE I ELEKTROFORETICHESKIE SVOYSTVA MALATDEGIDROGENAZY KHLOPCHATNIKA. In INTERNATIONAL SCIENTIFIC REVIEW OF THE PROBLEMS AND PROSPECTS OF MODERN SCIENCE AND EDUCATION (pp. 14-16).
Kuzieva, S. U., Imomova, D. A., & Duschanova, G. M. (2019). Structural features of vegetative organs Spiraea hypericifolia L., growing in Uzbekistan. American Journal of Plant Sciences, 10(11), 2086-2095.
Ravshanovich, J. R. (2023). Patterns in applied art of the Uzbek folk. European Journal of Arts, (1), 11-14.
Mukhamedovich, S. U., Haydarovich, A. A., Kholmuratovna, E. O., & Toshpulatovich, Y. B. (2023). The Question of Raising Young People in The Spirit of Craftsmanship. Journal of Advanced Zoology, 44.
Hasanov, S. (2025). Prospects For Overcoming Conflicts In Social Processes In Uzbekistan. Emerging Frontiers Library for The American Journal of Social Science and Education Innovations, 7(10), 71-75.
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