CHANGES IN THE TRANSPORT OF Ca2+ IN THE LIVER MITOCHONDRIA IN HEPATITIS WITH HELIOTRIN
Keywords:
ion, cell, nerve synapses, neurotransmitter, muscle fiber, adrenaline, glycogen, plasma membrane, cytoplasm.Abstract
It is very important to maintain a low level of Сa2+ for the normal functioning of the cell, because an increase in the amount of Сa2+, even for a short time, can directly express the effect of various factors: hormones, neuromediators, growth factors and antigens in the cellular response. Eukaryotic cells maintain a Сa2+ transport system in the plasma membrane, mitochondria, and endoplasmic reticulum.
References
Deryabina Yu.I., Isakova E.P., Zvyagilskaya R.A. Mitochondrial Сa2+ transport system: properties, regulation, taxonomic peculiarities. // J. Biochemistry. - Moscow, 2004. - T. 69.- #1. - P.114-127.
Zinchenko I.P., Kaymochinkov N.P. i dr. Regulation and functional significance of the receptor depends on Sa2+ signaling and mitochondria. Mitochondrii, cells and active forms of oxygen. - Pushchino, 2000. - S. 52-57.
Gunter T.E., Buntinas L., Sparagna G.C., et al. The Ca2+ transport mecha-nisms of mitochondria and Ca2+ uptake from physiological – type Ca2+ transients. // Biochem. Biophys. Acta. -2008. -V.1366. - P. 5-15.
Halestrap A.P., Davidson A.M. Inhibition of Ca2+-induced large amplitude swelling of liver and heart mitochondrial cyclosporin in probably caused by the inhibitor binding to mitochondrial-matrix, peptidilpolil cis-trans isomerase and preventing it interacting with the adenin nucleotide translocase. // Biochem. J, -2001. -V. 268. -P.153-160.
Hoex J. B. , Farber J. L., Thomas A. P., Wang X. L. Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver celes and implication for the mitochondrial permeablity transition. // Biochim Biophys. Acta. //2003. -V. 1271. -P. 93- 97.
Youle Y.T., Russell Smaili S.S., HSU J.H. Mitochondria in Ca2+ signaling and appoptosis. // J. Biomembr. – 2000. - V. 32. - Р. 35-46.
