THE POTENTIAL ROLE OF SYSTEMIC IMMUNITY IN STROKE-RELATED COMORBIDITIES
Keywords:
inflammation, long‐term outcome, stroke, systemic immunityAbstract
Immunological mechanisms have become a focus of current stroke research, with the modulation of neuroinflammatory pathways identified as a potential therapeutic approach for protecting the ischemic brain. Stroke not only triggers a local neuroinflammatory response, but also has a significant impact on systemic immunity, which is important to consider in the development of new treatments.
In this review, we will discuss the consequences of ischemic stroke on systemic immunity throughout the disease process, from the onset to long-term outcomes. We will also explore the underlying mechanisms of brain-immune communication and the potential role of systemic immunity in stroke-related comorbidities such as cardiac dysfunction, atherosclerosis, diabetes and infections. Finally, we will discuss how targeting systemic immunity after a stroke could improve long-term outcomes and reduce the risk of comorbidities in stroke patients.
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