INCREASED INFLAMMATORY RESPONSE IN UNSTABLE ANGINA

Abstract

The article offers contemporary perspectives on how inflammation contributes to atherogenesis. The study reviewed research on the function of endothelium local factors, including the build-up of smooth muscle cells, T and B lymphocytes, macrophages, matrix metalloproteinase (MMP), and high-sensitivity C-reactive protein (CRP). In coronary artery disease (CAD), oxidized low-density lipoprotein (OLDL) and CRP are directly linked to inflammatory arterial damage. Monocyte chemoattractant protein (MCB-1) and MMP-1 activate monocytes in inflammatory regions, which contribute significantly to the rupture of atherosclerotic plaque and the subsequent emergence of acute coronary problems. MMPs, tumor necrosis factor α (TNF-α), and granulocyte-macrophage colinear stimulating factor (GM-CSF) are all synthesized more when CRP and SLDL are present.