PROGNOSTIC ASPECTS OF NON-DEVELOPING PREGNANCY IN THE REPUBLIC OF UZBEKISTAN: CURRENT STATE OF THE PROBLEM AND PROSPECTS

Abstract

Non-developing pregnancy (NDP) remains one of the most significant problems in reproductive health, contributing substantially to the structure of reproductive losses worldwide, including in the Republic of Uzbekistan. The purpose of this article is to comprehensively analyze current data on the prognostic aspects of NDP, focusing on epidemiological features, risk factors, prediction methods, and the contribution of scientific research in the Republic of Uzbekistan. A systematic analysis of scientific publications, clinical guidelines, and protocols was conducted. It has been established that the frequency of NDP in Uzbekistan remains high, varying across different studies and regions, and constitutes a significant proportion of pregnancy losses. Among the key risk factors confirmed by local studies are infectious (especially urogenital infections and chronic endometritis), immunological (antiphospholipid syndrome, cytokine imbalance), endocrine disorders, and changes in the hemostasis system. In Uzbekistan, various methods for predicting NDP are available and used, including clinical assessment, ultrasound examination (determination of anembryonic pregnancy, absence of fetal heartbeat), biochemical markers (hCG, PAPP-A), genetic tests, and assessment of hemostasis parameters. Uzbek scientists have made significant contributions to the study of the etiopathogenesis and prognostic criteria of NDP; however, there is a need for further multicenter research, standardization of approaches, and wider implementation of modern prediction methods in clinical practice throughout the country. A conclusion was drawn about the importance of a comprehensive, personalized approach to NDP prediction and the need to improve the medical care system to reduce the frequency of this pathology and enhance the reproductive health of women in Uzbekistan.