HISTOLOGICAL AND CYTOMORPHOLOGICAL CHARACTERISTICS OF LEUKEMIC CELLS IN DIFFERENT TYPES OF LEUKEMIA

Yuldasheva Nodira Ergashevna

Authors

Yuldasheva Nodira Ergashevna Associate Professor, Department of Hospital Therapy and Endocrinology

Keywords:

leukemia, bone marrow, histology, cytomorphology, blasts, hematopoiesis, acute leukemia, chronic leukemia

Abstract

Leukemia represents a heterogeneous group of malignant disorders characterized by uncontrolled proliferation of abnormal hematopoietic cells within the bone marrow and peripheral blood. The histological and cytomorphological characteristics of leukemic cells serve as the foundation for classification, diagnosis, and prognosis of the disease. Each leukemia subtype—acute or chronic, myeloid or lymphoid—exhibits distinctive microscopic features that reflect the stage of cellular differentiation and the nature of malignant transformation. This article provides an overview of the histological organization of leukemic tissues and the cytomorphological variations of leukemic cells, emphasizing their diagnostic relevance in differentiating leukemia types and assessing disease progression.

References

Jaffe, E. S., Arber, D. A., Campo, E., Harris, N. L., & Quintanilla-Fend, L. (2022). WHO Classification of Tumours of Haematolymphoid Tumours. IARC Press.

Bain, B. J. (2015). Blood Cells: A Practical Guide. Wiley-Blackwell.

Orazi, A., Czader, M. B., & Thiele, J. (2019). “Bone marrow pathology in leukemia.” Modern Pathology, 32(1), 47–63.

Arber, D. A. et al. (2016). “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.” Blood, 127(20), 2391–2405.

Foucar, K., & Catovsky, D. (2017). Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches. Elsevier.

Исраилова, Г. М., Эшмурадова, С. Т., & Тураев, И. Э. (2010). ГИГИЕНИЧЕСКАЯ ОЦЕНКА ФАКТОРОВ РИСКА ЗАГРЯЗНЕНИЯ МЯСОМОЛОЧНОЙ ПРОДУКЦИИ, ПРОИЗВОДИМОЙ В УСЛОВИЯХ МАЛОВОДЬЯ. Профилактическая и клиническая медицина, (1), 41-43.

Nurumbetova, S. (2022). VAIN ASPECTS OF PRACTICAL RELIGIOUS EXAMINATION IN THE INVESTIGATION OF CRIMES RELATED TO PROHIBITED RELIGIOUS MATERIALS. Science and Innovation, 1(6), 108-113.

Nurumbetova, S. (2023). MODERN OPPORTUNITIES AND PROSPECTS FOR DEVELOPMENT EXPERT-CRIMINALISTIC ACTIVITY. Modern Science and Research, 2(9), 415-419.

Nurumbetova, S. (2022). ДИНИЙ МАЗМУНДАГИ ТАҚИҚЛАНГАН МАТЕРИАЛЛАР БИЛАН БОҒЛИҚ ЖИНОЯТЛАРНИ ТЕРГОВ ҚИЛИШДА ДИНШУНОСЛИК ЭКСПЕРТИЗАСИНИ ЎТКАЗИШ АМАЛИЁТИНИНГ МУҲИМ ЖИҲАТЛАРИ. Science and innovation, 1(C6), 108-113.

Khalimovich, R. B. (2023). Simplification of criminal proceedings: concept, content and importance. World Bulletin of Management and Law, 18, 51-54.

Brunning, R. D., & Bennett, J. M. (2018). “Cytomorphologic features of acute and chronic leukemias.” Seminars in Diagnostic Pathology, 35(3), 183–196.