CLINICAL, NEUROLOGICAL, AND CEREBRAL HEMODYNAMIC FEATURES IN PATIENTS WITH CHRONIC MIGRAINE
Keywords:
chronic migraine, headache, neurovascular mechanisms, neurological symptoms, cerebral hemodynamics, Doppler ultrasonography, cognitive function, cerebrovascular reactivity, physiological triggers.Abstract
Chronic migraine (CM) is a complex neurovascular disorder characterized by recurrent headache episodes accompanied by neurological dysfunction. The aim of this study was to evaluate the clinical symptom dynamics, neurological indicators, and cerebral hemodynamic parameters in patients with chronic migraine. The examined patients were assessed for headache duration, intensity, pulsation characteristics, associated symptoms (nausea, photophobia, phonophobia), and trigger factors. Neurological evaluation included cognitive function assessment, signs of autonomic dysregulation, somatovegetative changes, and condition-dependent focal symptoms. Cerebral hemodynamic analysis was performed using Doppler ultrasonography and functional neuroimaging methods to assess brain stability, blood flow velocity, and cerebrovascular reactivity. The results confirmed that interactions between central and peripheral neurovascular mechanisms play a key role in chronic migraine and provide a basis for optimizing both diagnostic and therapeutic approaches.
References
Goadsby P.J., Holland P.R., Martins-Oliveira M., Hoffmann J., Schankin C., Akerman S. Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiological Reviews. 2017;97(2):553–622.
Dodick D.W. A Phase-by-Phase Review of Migraine Pathophysiology. Headache. 2018;58(Suppl 1):4–16.
Ashina M., Buse D.C., Ashina H., Pozo-Rosich P. Migraine: Epidemiology and Systems of Care. Lancet. 2021;397(10283):1485–1495.
Charles A. The Pathophysiology of Migraine: Implications for Clinical Management. Lancet Neurology. 2018;17(2):174–182.
