COMPREHENSIVE CHEMICAL CHARACTERIZATION OF FERULA MOSCHATA EXTRACTS USING HPTLC, GC-MS, AND NMR SPECTROSCOPY
Keywords:
Ferula genus, Ferula moschata, HPTLC, resin, NMR, GC-MC, Umbelliferae, essential oil, extraction.Abstract
This study investigates the chemical composition and biological potential of Ferula moschata, a rare medicinal species from the Umbelliferae family. Using solvent chromatographic methods, and biological assays, the plant’s bioactive compounds were analyzed. The findings demonstrate the presence of coumarins, terpenes, flavonoids, and essential oil with significant antioxidant and antimicrobial activity. These results highlight the pharmacological relevance of Ferula moschata and suggest that further in vivo and clinical studies are required to validate its therapeutic applications
References
Ferula sumbul, Musk root. Medicinetraditions.com.Medicine Tradition.2021. Retrieved9 January 2022.
Baser, K.H.C., & Demirci, B. (2007). Chemistry of Ferula species. Natural Product Communications, 2(6), 489–496
Duke, J.A. (2002). Handbook of Medicinal Herbs. CRC Press
Iranshahi, M. (2012). Phytochemistry and pharmacology of the genus Ferula (Apiaceae). Pharmacognosy Reviews, 6(12), 141–156
Newman, D.J., & Cragg, G.M. (2020). Natural products as sources of new drugs over the nearly four decades. Journal of Natural Products, 83(3), 770–803.
Pignatti S., 1982. Flora of Italy, Edagricole, Bologna
Martin Crawford. Creating a Forest Garden: Working With Nature to Grow Edible Crops. UIT/GREEN BOOKS. ISBN-10: 1900322625. 2010.
Holtom. J. and Hylton. W. Complete Guide to Herbs. Rodale Press 1979 ISBN 0-87857-262-7
Khakimjonov L. S., Mukumov I. U., Rasulova Z. A. The genus Ferula L. in the flora of the Zarafshan Range // Bulletin of Science. - 2020. - Vol. 1. - No. 3 (24). – P. 111-116
Rakhimov S. Biological and morphological characteristics of Ferula foetidissima Regel et Schmalh Siberian Ecological Journal. - 2007. - T. 14. - No. 3. - S. 505-509
Zhumaniyazova F. F., Mukumov I. U., Shakirova Sh. F. The genus Ferula L. in the flora of the Jizzakh region // Bulletin of Science. - 2020. - Vol. 5. - No. 8 (29). – P. 64-75
Mukumov I. U. Distribution of species of the genus Ferula in the Nuratau Ridge // Bulletin of Science. - 2020. - Vol. 2. - No. 5 (26). – P. 136-141
Mukumov I. U., Usmonova N. R., Nurmuratova M. A. The genus Ferula L in the flora of the Turkestan Range // Bulletin of Science. - 2020. - Vol. 2. - No. 1 (22). - S. 268-274
Kablanova D. A., Mirzadinov R. A. A., Akymbekova L. D. Ferulas ( Ferula ) of Kazakhstan and their national economic significance // Bulletin of Science and Education. – 2020. – no. 20-1 (98). S. 18-21
Ergashova SI Biochemical properties of ferula and its application in medicine // Theoretical & Applied science. – 2021. – no. 6. - P. 640-642
Mohammadhosseini M., Mahdavi B., Shahnama M. Chemical composition of essential oils from aerial parts of Ferula gummosa ( Apiaceae ) in Jajarm Region, Iran using traditional hydrodistillation and solvent-free microwave extraction methods: A comparative approach /Journal of Essential Oil Bearing Plants. – 2015. – V. 18. – no. 6. - P. 1321-1328.
Eshkuvatov D.Kh. et al. Study of the qualitative and quantitative composition of Ferulla resins tochik ” // Izvestia. – no. 3. - S. 99-107 [10]. Bunyatyan ND Development of a pharmaceutical composition based on low molecular weight immunoactive peptides and stinky ferula : Cand . - Volgograd State, 2022. - 133
Sayfiddinova D.Sh., Ergashova Sh.I., Fazlieva N.T., Mukhammadiyev N.Q., Mukhamadiyev A.N. GC-MS chemical analysis of Ferula essential oil. Central Asian Journal of medical and natural sciences Volume: 04 Issue: 03 May-Jun 2023
Абдурахманов А.А., Халматов Х.Х. Лекарственные растения Средней Азии. – Ташкент: Медицина, 1987. – 520 с.
Кузнецова Г.А., Гаммерман А.Ф. Фармакогнозия лекарственных растений. – Москва: Медицина, 2002. – 640 с.
Saidkhodzhaev A.I., Tashkhodjaev B.Chemical constituents of Ferula sumbul root. Chemistry of Natural Compounds, 1998, Vol. 34(3), pp. 356–359
Iranshahi M., Rezaee R., Parhiz H. Bioactive compounds of Ferula species: chemistry and pharmacology. Iranian Journal of Basic Medical Sciences, 2018, Vol. 21(10), pp. 1123–1136.