CAUSES OF DEVELOPMENT AND CLINICAL FEATURES OF PYELONEPHRITIS IN CHILDREN
Keywords:
Pyelonephritis, urinary tract infection, children, kidney inflammation, pediatric nephrology, bacterial infection, renal parenchyma, clinical symptoms, urinary tract anomaliesAbstract
Pyelonephritis is one of the most common infectious diseases of the urinary system in childhood and represents a serious medical and social problem. The disease is characterized by inflammatory damage to the renal parenchyma and the pelvicalyceal system, mainly caused by bacterial infection. In pediatric practice, pyelonephritis often develops due to ascending infection from the lower urinary tract and is associated with congenital anomalies, immune immaturity, and functional disorders of the urinary system. The early diagnosis and proper treatment of pyelonephritis are extremely important because untreated or recurrent infections may lead to renal scarring, hypertension, and chronic kidney disease. This article analyzes the main etiological factors, pathogenesis, and clinical manifestations of pyelonephritis in children based on scientific literature. Particular attention is given to risk factors, diagnostic approaches, and characteristic symptoms observed in pediatric patients.
References
Kliegman R., St. Geme J. Nelson Textbook of Pediatrics. 21st ed. Philadelphia: Elsevier, 2020, pp. 2761–2765.
Mattoo T., Shaikh N., Nelson C. Contemporary Management of Urinary Tract Infection in Children. Pediatrics, 2021, Vol.147(2), pp. 1–10.
Tullus K., Shaikh N. Urinary tract infections in children. The Lancet, 2020, Vol.395, pp. 1659–1668.
Elder J. Urinary Tract Infections. Pediatric Nephrology Journal, 2019, Vol.34, pp. 197–210.
Subcommittee on Urinary Tract Infection. Clinical Practice Guideline for UTI in Children. Pediatrics, 2016, Vol.138(6), pp. 1–15.
Coulthard M. Using urine tests to detect kidney infection in children. Archives of Disease in Childhood, 2019, Vol.104, pp. 473–478.
Salo J., Ikäheimo R., Tapiainen T. Childhood urinary tract infections and vesicoureteral reflux. Pediatric Nephrology, 2018, Vol.33, pp. 1463–1471.
Stein R., Dogan H., Hoebeke P. Urinary tract infections in children: EAU Guidelines. European Urology, 2015, Vol.67, pp. 546–558.
Freedman A. Urologic Diseases in North America Project. Journal of Urology, 2017, Vol.198, pp. 1220–1228.
Hoberman A., Wald E. Urinary tract infections in young febrile children. The New England Journal of Medicine, 2018, Vol.348, pp. 195–202.
Shaikh N., Morone N. Prevalence of renal scarring in children after UTI. Pediatrics, 2017, Vol.126, pp. 1084–1091.
Flores-Mireles A., Walker J. Urinary tract infections: epidemiology and pathogenesis. Nature Reviews Microbiology, 2015, Vol.13, pp. 269–284.






Azerbaijan
Türkiye
Uzbekistan
Kazakhstan
Turkmenistan
Kyrgyzstan
Republic of Korea
Japan
India
United States of America
Kosovo