LOCKING INTRAMEDULLARY OSTEOSYNTHESIS IN THE TREATMENT OF DIAPHYSEAL FRACTURES OF LONG TUBULAR BONES: MODERN OPPORTUNITIES, MORPHOLOGICAL BASIS OF REPARATIVE REGENERATION, AND ANALYSIS OF CLINICAL OUTCOMES

Muzaffar Fayzimatov,Asqarov Shoxruxbek Erkinjon o‘g‘li

Authors

Muzaffar Fayzimatov,Asqarov Shoxruxbek Erkinjon o‘g‘li Central Asian Medical University

Keywords:

BIOS, intramedullary nail, diaphyseal fracture, reparative osteogenesis, bone callus, osteoblasts, osteoclasts, angiogenesis, micromobility, stable-dynamic fixation, compartment syndrome.

Abstract

This study is devoted to one of the most relevant areas of modern traumatology and orthopedics — the effectiveness of locking intramedullary osteosynthesis (BIOS) in the treatment of fractures of large tubular bones (femur, tibia, and humerus). The article analyzes the mechanisms of post-traumatic bone tissue regeneration, the biomechanical characteristics of BIOS rods, and their effect on intraosseous hemodynamics from a pathomorphological perspective[1,2].

Based on the results of multicenter clinical studies conducted between 2024 and 2026, as well as rehabilitation stages and quality-of-life assessment scales (SF-36, Harris score), the superiority of the BIOS method over traditional treatment techniques is statistically demonstrated.

References

Rockwood and Green's Fractures in Adults, 10th Global Edition, 2024.

AO Principles of Fracture Management, 3rd Edition (Revised 2025), Thieme Publishers.

Journal of Bone and Joint Surgery (JBJS): "The Evolution of Intramedullary Nailing: 2026 Review".

Azizov M.J., "Travmatologiya va ortopediya: Darslik", Toshkent, 2024.

Orthopaedic Trauma Association (OTA) Annual Statistical Report, 2025.

The Lancet: "Surgical Innovation and Global Burden of Musculoskeletal Injuries", 2026.

Karimov A.M., va boshqalar. (2026). O‘zbekistonda angionevrologiyaning dolzarb muammolari. Toshkent: O‘zbekiston Milliy Ensiklopediyasi.

Thompson J.R., et al. (2024). Neuropathology of Ischemic Stroke: From Molecular to Cellular Changes. Journal of Neuroscience Research.

Rahmatjonovna, I. N. (2024). Fast foods are the potential of human health. Ethiopian International Journal of Multidisciplinary Research, 11(05), 365-369.

Isaqova, N. (2022). Bolalarning antropometrik ko’rsatkichlarini turli omillarga bog’liqligi. Science and innovation, 1(D8), 1000-1003.

Рахматжоновна, И. Н. Алиментарного ожирение и репродуктивное здоровье женшин в современном аспекте физической реабилитации. O'zbekiston harbiy tibbiyoti, 4(4), 368-370.

Isaqova, N. (2022). Қабзиятнинг болалар антропометрик кўрсаткичларига таъсири. Science and innovation, 1(D8), 888-892.

Isaqova, N. (2024). Microscopic examination of sputum. Развитие и инновации в науке, 3(6), 63-66.

Исакова, Н., & Усмонова, Г. (2024, June). Лабараторная диагностика трихомониза. In международная конференция академических наук (Vol. 3, No. 6, pp. 59-65).

Raxmatjonovna, I. N. (2024). Labaratory diagnostics of trichomonisis disease. Ethiopian International Journal of Multidisciplinary Research, 11(05), 496-499.

Raxmatjonovna, I. N. (2023). The problem of acceleration of children's development (literature review). International Multidisciplinary Journal for Research & Development. Volume10, (12), 160-164.

Исакова, Н., & Усмонова, Г. Кишечный дисбактериоз//Models and methods in modern science.–2024. Т, 3, 106-112.

Raxmatjonovna, I. N. The most pressing problem today is iodine deficiency. World Bulletin of Public Health, 23, 97-100.

Raxmatjonovna, I. N. Anthropometric indicators of children. Scientific Impulse, 1(5), 883-887.

Isakova, N. R. (2021). The effect of constipation due to diseases of the colon on the anthropometric parameters of children. Asian journal of multidimensional research, 10(5), 666-669

Soliyev B.Q. (2025). Ishemik insult diagnostikasida neyrovizualizatsiya usullarining klinik-morfologik tahlili. Tibbiyot va zamon jurnali.

Miller K.S. & Smith L. (2024). Advances in Neuroprotective Strategies and Penumbra Recovery. New England Journal of Medicine.