PATHOPHYSIOLOGICAL CHANGES IN THE LIVER DURING ACUTE INFLAMMATION

Baxodirova Gulhayo Baxtiyorovna, Nuriddinov Hojibek Akbarovich

Authors

Baxodirova Gulhayo Baxtiyorovna, Nuriddinov Hojibek Akbarovich Third year Student, Bukhara State Medical Institute named after Abu Ali Ibn Sina

Keywords:

acute inflammation, liver, pathophysiology, hepatocyte, Kupffer cells, sinusoidal endothelial cells, microcirculation, cytokines, inflammatory mediators, TNF‑α, IL‑1β, IL‑6, IL‑10, TGF‑β, oxidative stress, reactive oxygen species (ROS), antioxidant system, glutathione (GSH), superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), lipid peroxidation, mitochondrial dysfunction, liver injury, apoptosis, necrosis, regeneration, immune response, liver function, clinical biomarkers, therapeutic approaches

Abstract

This review highlights the pathophysiological changes that occur in the liver during acute inflammation, based on a systematic analysis of scientific research and literature. The article examines microcirculatory disturbances, hepatocyte injury mechanisms, cytokine and inflammatory mediator imbalances, oxidative stress, and the role of the antioxidant system. Findings from both domestic and international studies underscore the importance of understanding liver injury and functional disturbances, monitoring these changes, and developing effective therapeutic strategies. The review provides theoretical and practical insights for clinical practice and further research.