STUDY OF THE ASSOCIATION OF GENETIC POLYMORPHISM OF SOD2 (Ala16Val) WITH THE DEVELOPMENT OF CHRONIC TONSILLITIS

Sultonov Bekzod Olimboy o’g’li, Esamuratov Aybek Ibragimovich

Authors

Sultonov Bekzod Olimboy o’g’li, Esamuratov Aybek Ibragimovich Tashkent State Medical University

Keywords:

chronic tonsillitis, genetic polymorphism, SOD2 (Ala16Val), allele, genotype, risk of development.

Abstract

This study is devoted to investigating the role of the SOD2 (Ala16Val) gene polymorphism in the development of chronic tonsillitis and its association with different clinical forms of the disease. The study included 94 patients aged 3 to 55 years diagnosed with chronic tonsillitis, as well as 90 conditionally healthy individuals examined in the Khorezm region between 2021 and 2025. Depending on the clinical presentation, patients were divided into groups with simple, toxic-allergic form I, and toxic-allergic form II.

Molecular genetic analysis was performed using real-time polymerase chain reaction (PCR). Statistical analysis was carried out using the chi-square (χ²) test and odds ratio (OR).

The results demonstrated that the presence of the minor Val allele and the Val/Val genotype of the SOD2 (Ala16Val) polymorphism is significantly associated with an increased risk of developing chronic tonsillitis. Specifically, the Val allele increases the risk by 1.7 times, while the Val/Val genotype increases it by 2.3 times. Furthermore, this genetic marker was found to play a significant role in the development of both simple and toxic-allergic forms of the disease.

In conclusion, the SOD2 (Ala16Val) gene polymorphism can be considered an important genetic marker for predicting the risk of chronic tonsillitis and may be useful in selecting individualized treatment strategies.

References

Abraham ZS et al. Prevalence and bacteriology of tonsillitis among patients attending otorhinolaryngology Department at Muhimbili National Hospital, Dar es Salaam-Tanzania //Medical journal of Zambia. – 2019. – T. 46. – No. 1. – pp. 33-40.

Abu Bakar M. et al. Chronic tonsillitis and biofilms: a brief overview of treatment modalities //Journal of inflammation research. – 2018. – S. 329-337.

Andreychyn MA et al. Thermographic differential diagnosis of acute tonsillitis and exacerbation of chronic tonsillitis //Wiadomości Lekarskie. – 2020. – T. 73. – No. 3. – pp. 417-422.

Esamuratov AI, Ermatov NJ. Features of the occurrence of single-nucleotide polymorphism il10 (c592a) among patients with purulent-inflammatory diseases of the middle ear and assessment of its contribution to the mechanisms of disease formation // British Medical Journal . 2022, Vol. 1 No. 1 : 57-64 . (14.00.00; No. 6).

Esamuratov A.I., Zh.F. Shamsiev, M. A. Mirzaeva. Features of the distribution of allelic polymorphisms of inflammatory (TNF (G308A), IL2 (T330G), IL6 (C174G), IL10 (C592A)) cytokine genes in pyoinflammatory diseases of the middle ear // European journal of molecular medicine, Vol. 2 No. 5 (September 2022), P.70-73

Esamuratov A.I. , Mirzaeva M.A., Shamsiev Zh.F. Immune and molecular genetic aspects of the formation of chronic reliable otitis media ( csom ) // Evrosiyo pediatriya akhborotnomasi. - Toshkent . - 2021; 3 (10): -B. 2-6 ( ОАК Раёсатининг 2019 йил 31 октябрдаги 270/8.2-сон қарори ).

Esamuratov AI, Mirzayeva MA, Shamsiyeva JF. Genetic predictors for the formation of chronic purulent otitis media // British Medical Journal . 2021, Vol. 2 No. 1 : 159-164 (14.00.00; No. 6).

Esamuratov AI, Ermatov NJ. Features of the occurrence of single-nucleotide polymorphism il10 (c592a) among patients with purulent-inflammatory diseases of the middle ear and assessment of its contribution to the mechanisms of disease formation // British Medical Journal . 2022, Vol. 1 No. 1 : 57-64 . (14.00.00; No. 6).

Gaździcka J. et al. Selected SNPs of FCN2 associated with chronic tonsillitis in the adult population //Genes. – 2023. – T. 14. – No. 2. – S. 242.

Guntinas-Lichius O. et al. Treatment of recurrent acute tonsillitis—a systematic review and clinical practice recommendations //Frontiers in surgery. – 2023. – T. 10. – P. 1221932.

Kostić M. et al. Analysis of tonsil tissues from patients diagnosed with chronic tonsillitis—microbiological profile, biofilm-forming capacity and histology //Antibiotics. – 2022. – T. 11. – No. 12. – P. 1747.

Marlina L., Barreto JCHA, Poluan FH Analysis of Chronic Tonsillitis A Case Study //Asian Journal of Advanced Research and Reports. – 2025. – T. 19. – no. 3. – S. 301-310.

Matkarimova D.S., Karimov Kh. Ya., Boboev K.T. Features of the renin-angiotensin system gene polymorphism in patients with immune microthrombovasculitis in Uzbekistan // Bulletin of Hematology. 2022. No. 2.

Nimmana BK, Paterek E. Tonsillitis //StatPearls [Internet]. – StatPearls Publishing, 2025.

Shukurullayevna BS et al. Modern laboratory diagnostics of tonsillitis //Web of Teachers: Inderscience Research. – 2025. – T. 3. – No. 1. – S. 61-65.

Tzelnick S. et al. Long-term outcomes of tonsillectomy for recurrent tonsillitis in adults //The Laryngoscope. – 2020. – T. 130. – No. 2. – pp. 328-331.

Yarmukhamedova, N. F., Matkarimova, D. S., Bakieva, S. K., & Salomova, F. I. (2021). Features of the frequency of distribution of alleles and genotypes of polymorphisms of the gene Tnf-A (G-308a) in patients with rhinosinusitis and the assessment of their role in the development of fhis pathology.