THE ROLE OF STRESS FACTORS IN SEVERE CONGENITAL ANOMALIES OF THE UROGENITAL SYSTEM DURING ORGANOGENESIS IN CHILDREN

Xudaynazarov X.X., Xotamov X.N., Fayzullayev T.S., Zulpikariyev D.D., Axmedov A.I.

Authors

Xudaynazarov X.X., Xotamov X.N., Fayzullayev T.S., Zulpikariyev D.D., Axmedov A.I. Tashkent state medical university, Tashkent, O`zbekiston

Keywords:

Congenital anomalies, urogenital system, epispadias, bladder exstrophy, maternal stress, pregnancy, organogenesis, fetal development, urinary incontinence, risk factors, psycho-emotional stress.

Abstract

The aim of this study was to investigate the impact of parental, particularly maternal, stress experienced during pregnancy on the development of severe congenital anomalies of the urogenital system. A total of 118 children aged 1 to 15 years with various forms of epispadias and bladder exstrophy were clinically examined. Analysis of anamnestic data revealed that 104 patients (88.1%) were exposed to different types of stress during the organogenesis period of fetal development. The obtained results indicate that psycho-emotional factors play a significant role in the development of severe congenital anomalies of the urogenital system, especially those complicated by urinary incontinence. Intense and prolonged stress during pregnancy may negatively affect normal fetal development, leading to structural and functional abnormalities of the urinary and reproductive systems. [2]Therefore, reducing stress factors in pregnant women, ensuring psychological stability, and strengthening early preventive measures are essential for decreasing the risk of congenital anomalies.

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