PATHOANATOMICAL BASIS OF BLOOD COAGULATION SYSTEM DISORDERS IN COVID-19 INFECTION
Keywords:
COVID-19, SARS-CoV-2, hemostasis, thrombosis, microthrombosis, disseminated intravascular coagulation, endothelial dysfunction, pathoanatomical changes, multiple organ failure.Abstract
COVID-19 infection manifests not only as respiratory system damage but also as a systemic disease with profound hemostasiological changes in the body. As a result of SARS-CoV-2 virus infection, acute activation of the blood coagulation system, endothelial dysfunction, microthrombosis, disseminated intravascular coagulation (DIC syndrome), and multiple organ failure develop. This article extensively covers the pathoanatomical basis of blood coagulation system disorders in COVID-19 infection[1,2,3], morphological features, microcirculatory changes, mechanisms of thrombotic complications, and their clinical significance.
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