ETIOPATHOGENESIS OF CEREBROVASCULAR DISORDERS AND COMPLEX APPROACHES TO THEIR TREATMENT

Fayziyeva Shaxlo Raxmanovna

Authors

Fayziyeva Shaxlo Raxmanovna Center for the Development of Professional Qualifications of Medical Personnel Tashkent, Uzbekistan

Keywords:

cerebrovascular diseases, stroke, hypertension, atherosclerosis, neuroprotection, microcirculation, MRI, complex therapy.

Abstract

Cerebrovascular diseases (CVDs) represent chronic pathological processes characterized by disturbances in cerebral circulation leading to neuronal hypoxia, metabolic dysfunction, and cognitive decline. This study aimed to analyze the main etiopathogenetic mechanisms, diagnostic approaches, and evaluate the clinical effectiveness of comprehensive treatment strategies for CVD. The analysis was based on data from multicenter clinical studies conducted between 2018 and 2024 in Uzbekistan, Russia, and Germany, including 3,140 patients. The results indicate that arterial hypertension, atherosclerosis, endothelial dysfunction, diabetes mellitus, and oxidative stress play major roles in disease development. A multimodal therapeutic strategy (antihypertensive, antiplatelet, lipid-lowering, neuroprotective, and rehabilitative interventions) improved cognitive performance by up to 45% and reduced the risk of recurrent stroke by 38%.

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